Based on its efficacy in preclinical cellular and in vivo models of renal injury, including a diabetic nephropathy model, CTP-499 has the potential to to protect kidney function and slow disease progression when added to existing therapy.. CTP 499 one deuterium includes new chemical entity that has been derived from an active metabolite of a drug approved for other indications. It possesses a pleiotropic mechanism of action with anti-inflammatory, anti-oxidative and anti-fibrotic properties from the current standard of care.
Better safety, tolerability and / or efficacy.. Diabetic nephropathy is associated with diabetes and is the leading cause of chronic kidney disease in the United States. Current standard of care for kidney disease is treatment with blood pressure lowering drugs renin renin-angiotensin cascade, including angiotensin-converting enzyme inhibitors and angiotensin receptor blockers . Despite the use of current treatments, many patients progress to renal failure. There is a critical need for agents with novel that further delay or prevent the decline of kidney function. Model.
About deuteriumDeuterium is a safe, non-radioactive relative of hydrogen that can be isolated from sea water and has been used extensively in human metabolic and clinical studies used.Gluten hypersensitivity Gluten speed will be at a enraged epidemics today. Gluten intolerance is not a sickness and therefore has not a cure. Gluten speed by the consumption by the consumption of products included the gluten. The only way to avoid its complications of is stay away from certain foods that contain gluten. There is thirty-five are caused be caused by consumption of gluten given in a review in of in New England Journal of Medicine -. Few of these symptoms include: arthritis, depression, frequent headaches, Fatigue, lost of muscle coordination, osteoporosis, a compromised immune system, growth of fungi, organ inflammation, weight loss / weight increase and malnutrition.
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