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Announced the initiation of two clinical studies for the nucleotide analogues ALS-2200 and ALS-2158 today, which are inhibitors of the hepatitis C NS5B polymerase. The studies will evaluate the safety and tolerability of ALS-2200 and ALS-2158 in healthy volunteers followed by a seven-day evaluation to observe the effects on viral kinetics in people who have persistent genotype-1 hepatitis C. Data are anticipated in the next quarter of 2012, which could enable the initiation of research to evaluate multiple all-oral, interferon-free combination regimens for chronic hepatitis C in the second half of 2012.